It's definitely a console/game pad game. The camera can be frustrating with a controller, don't know about the mouse controls.
I'd give it a shot dude, it's somewhere between Yakuza, GTA4 and Saints Row. Thankfully, all of the good parts and not the annoying ones. Minus a few camera quirks and a few frustrating combat difficulties (probably down to my skill level more than it actually being a gameplay issue) its a great game.
Some of the gunplay/hand combat stuff is just awesome to watch/play. It's worth a crack. IGN have said its a standalone game, not something to tide over between the next GTA/Saints game. I'd agree. The story is pretty good too, quite immersive, and at times I found myself forgetting completely that Shen is an undercover cop, not a Yakuza. Which is sort of the point, all the stuff id read previously stated that the story revolves around the blurred line between good/bad, loyalty/the law, friends/criminals.
It does it very well.