Not sure why so many are having issues with bigger video cards that are failing to work. I use a 4870 and have most settings maxed on 1680x1050. 100FPS in most and drops to 50 odd when major action/explosion, still very stable and playable.
The setting for CPU multi-core from "0" to "1" helped a little and now see more balanced use of my 8 cores (2x quad-core Xeon's).
For some stupid reason, the game installed (after a lot of **** with bloody steam) and set the multi-GPU enabled for some reason, I only have a single card.
I have occasional sound quirks that only happen when entering some maps, I use a SB Audigy ZS rather than on-board poop.
Slow game loads suck dogs balls but I will leave it at maybe thing my Raptors are just too slow.... Pfffft
Excessive long waits for the games to quit and piss-off.
This all aside, the biggest gripes seen so far is the random high pings of both myself and other players. We can all be under 80 then all of a sudden, a couple will go 350-450 for 5-10 seconds then back again. Worse is when people on 3G connections decide they want to games and just hold high pings the whole time for which Node doesn't use "Low-Ping Only" servers which is a pitty.