Goodsprings wasn't that annoying in terms of bugs. Aside from items falling through the ground when I tried to pick them up, I just shrugged it off and assumed I'll get them elsewhere. No spinning heads, no crouchhopping, seemed okay.
After leaving Goodsprings, I lost any kind of stability and order. I'll open a locker, 360 would freeze. I'll try and maintain clothing or weapons, either the game would freeze or worse, the items I was trying to merge would disappear, I'll try and switch weapons, the 360 would freeze. It pretty much turned into Fallout: Bugged Vegas with any input from my controller causing the 360 to freeze up.
Not a happy camper at all. I'm not sure if it sends a message, but I refuse to wait for patching. As much as I love Fallout, this is going straight back to EB in the morning for a refund. I have other things I can spend my money on and get enjoyment out of without waiting for patches just to get some resemblence of playability.