One thing that never seems to affect the hero of any given video game is the awful weight of their actions. Killing another person isn’t something most people can deal with easily, and a lot of people die because of the actions of game characters. It is often to save their own life, yes, but in the real world, people are heavily affected by taking the lives of others. It’s a big, big reason so many people suffer from Post Traumatic Stress Disorder in the armed services. It is very, very difficult to put that level of conscious or subconscious guilt and shame aside.
Some people don’t have that problem, however. Those people are called sociopaths.