Running game in windowed mode seems to be the way to go.
By Tim Colwill on October 12, 2012 at 2:01 pm
Some ATI users are reporting that Dishonored not only isn’t working for them, but crashes out leaving an exceptionally long error message about unavailable binaries.
If this is happening to you, you’re in luck — a solution has been found. Right-clicking on Dishonored in Steam, selecting ‘Launch Properties’ and adding -windowed to the end will force the game to boot up in a window and — apparently — seems to be working to stop the crashing.
The solution was suggested by a Bethesda moderator, who also advised that “I can’t say I know what it means or what the problem is, but maybe someone else does. The devs are checking this forum so they’ll be aware at least”.
If you still aren’t sure about Dishonored, why not read our massive review? There’s a code at the end to get it for $45 that expires today, as well!